[摘要]目的:探讨中药治女性痤疮的效果。方法:采用随机,对照方法。实验组内服消痤汤1次/日:对照组外用阿达帕林凝胶1次/晚,两组均治3个月为1个疗程,观察皮疹情况。同时实验组治前后检测血清睾酮、雌二醇水平,并作统计。结果:实验组总有效率82.9%;对照组总有效率81.8%。两组有效率比较P>0.05,差异没有显著性。实验组治后睾酮水平明显下降,雌二醇变化不大。结论:消痤汤能够用于治女性痤疮。
Clinical study on treatment of female acne vulgaris with anti-acne decoction
Abstract:Objective To observe the curative effect of Chinese Medicine for female acne vulgaris.Methods Randomand comparative methods were used.The experiment patients were treated with anti-acne decoction 1 time per day.The control patients were treated with adapalene 0.1%gel topically 1 time daily Both groups were treated for 3 monthsand observed the local lesion.Serum sex hormone levels were detected in front of treatment and after treatment.ResultsExperiment group has an total effective rate of 82.9%.and 81 8%in controlled group.Two groups have no statisticsdifference(P>O.05)Serum levels 0f testosterone hormone in experiment group after treatment were lower than those infront of treatment,and no statistics difference about the serum levels ofestradiol Conclusion Chinese Medicine hasgood efficiency in treating female acne vulgaris.
Key words:Chinese Medicine:acne:sex hormone
痤疮是一种毛囊皮脂腺的慢性炎症,影响着你生活中的日常美容。随着人们生活水平的不断提高,痤疮的发病率逐年增加。临床上以面部的粉刺、丘疹、脓疱或结节、囊肿为特征,易回归发作。痤疮又相当于中医学的“肺风粉刺”。传统中医学认为面部皮肤主要为肺经与胃经所司,痤疮是由于肺胃血热所致。《医宗金鉴·外科心法要诀》:“肺风粉刺,此证由肺经血热而成。每发于面鼻,起碎疙瘩,形如黍屑,色赤肿痛,破出白粉汁,日久皆成白屑,形如黍米白屑。宜内服枇杷清肺饮,外敷颠倒散,缓缓自收功也。“传统中医对痤疮多从肺、从热论治,一般用清泻肺胃、凉血解毒的方法治。我们经多年的临床实践.发现痤疮还有肾阴不足,而肺胃之阴得不到补充和滋养,以致肺胃阴虚血热,上熏头面,女性特别明显。于2005年3月~2008年3月我们用自拟消痤汤治女性痤疮,取得较为满意的效果,并检测性激素以探讨其机制。
1资料和方法
1.1临床资料:患者均来自我院皮肤科门诊,共68例。全部为女性,年龄13~4l岁,平均18.5岁,病程2个月~7年。根据Pillsbury分类法,把痤疮分为I~IV度。68例女性痤疮以轻、中度表现为主。I度(轻度)主要为表现在脸部散发的黑头粉刺或炎症性丘疹:II度(中度)为I度基础上炎症皮疹增多和伴有脓疱:III度(重度)为在II度基础上伴有结节等深在性炎症性皮损,且皮损发布扩展至颈部、胸背部:IV度为在III度的基础上皮损进一步加重,伴有囊肿和形成瘢痕。所有病例符合赵辨《临床皮肤病学》寻常痤疮的诊断标准。中医诊断标准属于阴虚火旺、肝经郁热型。自觉次要症状有:月经前皮疹加重、乳房胀痛、心烦、失眠、大便干、小便黄。且实验组与对照组的临床资料经统计学处理(t检验),均无显著性差异(P>0.05)。20例健康体检女性来自我院体检中心,均无系统性疾病。